LCC-12 (formaat)

LCC-12 (formate) is a copper (II) chelator and a derivative of the biguanide metformin. LCC-12 (formate) reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+. LCC-12 (formate) reduces IL-1β, IL-2, IL-6, IL-8, and TNF-α levels, as well as JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) levels in primary human cytokine-activated monocyte-derived macrophages (MDMs). LCC-12 (formate) reduces the number of CD80+ and CD86+ cytokine-activated MDMs. LCC-12 LCC-12 (formate) improves survival in a mouse model of sepsis induced by LPS or cecal ligation and puncture[1].

12352211

Interleukin Related; IRAK; JAK; NADH Dehydrogenase; STAT; TNF Receptor

Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Inflammation/Immunology

99.9

NC(NC(NCCCCCCCCCCCCNC(NC(N)=N)=N)=N)=N.O=CO

C17H38N10O2

414.55

[1]Solier S, et al. A druggable copper-signalling pathway that drives inflammation. Nature. 2023 May;617 (7960) :386-394.

Blue Ice

-20°C (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-W722277A/LCC-12-formate-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported