LCK Antibody - N-terminal regio : HRP (ARP54524_P050-HRP)

Lymphocyte-specific protein tyrosine kinase

LSK, YT16, IMD22, p56lck, pp58lck

3932

P06239-2

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the N-terminal region of Human LCK

LCK is a member of the Src family of protein tyrosine kinases (PTKs) . It is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules.

LZTS2; CDKAL1; BAG6; UBC; WASL; WAS; env; SMAD3; SMAD2; MAPK1; HSP90AA1; Mbp; HAVCR2; PTPN22; G3BP1; nef; LAT; KHDRBS1; ADAM15; ZAP70; PAK2; LCK; CBL; SOCS3; SOCS2; SOCS1; IL2RB; CISH; YWHAQ; AJUBA; CD5; CBLB; SKAP1; SYK; SOS1; CD38; CD247; CD3E; FAM174A

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%; Sheep: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

39kDa

Wet Ice

363

LCK

LCK

Rabbit

Tyrosine-protein kinase Lck

ENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALH