Lck-antilichaam [8E5F9/4B2C7]

Lck (lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.

3932

P06239

P06239

Human

Ni-NTA purified truncated recombinant Lck expressed in E. Coli strain BL21 (DE3) .

8E5F9 / 4B2C7

Unconjugated

Primary Antibodies

Signal Transduction, Immunology

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

Lck monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2a

LCK

Lymphocyte-specific protein tyrosine kinase

Homo sapiens

Mingjian Shi, John C. Cooper, Chao-Lan Yu. Mol. Cancer Res., Jan 2006; 4: 39–45

Robert F. Stachlewitz, Michelle A. Hart, Brian Bettencourt. J. Pharmacol. Exp. Ther., Oct 2005; 315: 36–41.

Ibrahim Y. Hawash, Kamala P. Kesavan, Anthony I. Magee. J. Biol. Chem., Feb 2002; 277: 5683–5691.

Leukocyte C-terminal Src kinase, LSK, YT16, p56lck, pp58lck

ELISA, WB

125474