LD78-beta/CCL3L1

LD78-beta is a CC chemokine that is closely related to MIP-1 alpha. It signals through the CCR5 receptor and the beta-chemokine receptor, D6. LD78-beta has been shown to exhibit potent activity in HIV suppression assays. Recombinant human LD78-beta is a 7.7 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

CCL3L1

6349

P16619

NP_066286.1

NM_021006.4

17q21.1

Human

Human

APLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPSV IFLTKRGRQV CADPSEEWVQ KYVSDLELSA

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract mouse BaF3 cells expressing the CCR5 receptor using a concentration range of 5-25 ng/ml.

70

Lyophilized

7.7 kDa

E. coli