LDL Receptor (LDLR) Mouse Monoclonal Antibody [Kloon ID: LBI8D12]

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Carrier-free (BSA/glycerol-free) LDLR mouse monoclonal antibody, clone LBI8D12

FH; FHC; FHCL1; LDLCQ2

Homo sapiens low density lipoprotein receptor (LDLR), transcript variant 1, mRNA.

3949

P01130

Unconjugated

Endocytosis

Endocytosis

WB 1:2000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

LDLR

https://www.ncbi.nlm.nih.gov/gene/?term=3949

https://www.uniprot.org/uniprot/P01130