LDLR-eiwit (C-muis IgG1-Fc, mens)

LDLR

FH, FHC, FHCL1, LDLCQ2

C-mouse IgG1-Fc

< 1.0 EU per μg protein as determined by the LAL method.

> 85 % as determined by SDS-PAGE.

1.Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag (Cat. No. 10231-H05H) on ProA Biosensor, can bind Recombinant Human PCSK9 (D374Y) Protein, His Tag (Cat. No. 29698-H08H1) with an affinity constant of 2.57nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested) . 2.Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag (Cat. No. 10231-H05H) on ProA Biosensor, can bind Human PCSK9 / NARC1 (D374Y, V474I, G670E) Protein, His Tag (Cat. No. 10594-H08H1) with an affinity constant of 3.08nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested) . 3.Loaded Recombinant Human LDLR/LDL Receptor Protein, mFc Tag (Cat. No. 10231-H05H) on proA Biosensor, can bind Recombinant Human PCSK9 Protein, His Tag (Cat. No. 29698-H08H2) with an affinity constant of 12.800 nM as determined in BLI assay (Sartorius Octet RED384) (QC tested) . 4.Immobilized Recombinant Human LDL Receptor Protein (Fc Tag) (Cat: 10231-H05H) at 2 μg/mL (100 μL/well) can bind Recombinant Human PCSK9 / NARC1 (D374Y) Protein (His Tag) (Cat: 29698-H08H1), the EC50 is 10-30 ng/mL (QC tested) . 5.Immobilized Recombinant Human LDL Receptor Protein (Fc Tag) (Cat:10231-H05H) at 2 μg/mL (100μL/well) can bind Recombinant Human PCSK9 / NARC1 (D374Y) Protein (His Tag) (Cat: 29698-H08H1), the EC50 is 12-36 ng/mL. Recombinant Human PCSK9 Protein (wild type, His Tag) (Cat:29698-H08H2) is verified bind to Human LDL Receptor Protein (Fc Tag) (Cat:10231-H05H) wtih lower affinity (Routinely tested) .

Met1-Arg788

The recombinant human LDLR consists of 1001 amino acids and predicts a molecular mass of 111.2 kDa.

Human