LEMD2 Antilichaam

LEMD2 Antibody: The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.

221496

Q8NC56

NP_851853

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

LEMD2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

LEMD2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LEMD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of LEMD2 are known to exist; this antibody will detect only the longer isoform.

LEMD2

Cat. No. 17-201 - 3T3/BALB Cell Slide

LEM domain containing 2

Homo sapiens

Brachner A, Reipert S, Foisner R, et al. LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins. J. Cell Sci. 2005; 118:5797-810

Huber MD, Guan T, and Gerace L. Overlapping functions of nuclear envelope proteins NET25 (Lem2) and Emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Mol. Cell. Biol. 2009; 29:5718-28.

LEMD2 Antibody: NET25, dJ482C21.1, LEM domain-containing protein 2, hLEM2

ELISA, WB, ICC, IF

31044432

Liquid