LEMD3 Antilichaam

LEMD3 Antibody: LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.

23592

Q9Y2U8

NP_055134

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction

LEMD3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1320 - Human Colon Tissue Lysate

1 mg/mL

LEMD3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LEMD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2

LEMD3

LEM domain containing 3

Homo sapiens

Hellemans J, Preobrazhenska O, Willaert A, et al. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. Nat. Genet. 2004; 36:1213-8.

LEMD3 Antibody: MAN1, MAN1, Inner nuclear membrane protein Man1, LEM domain-containing protein 3

ELISA, WB, IHC-P, IF

7706607

Liquid