Lenalidomidehemihydraat
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
847871-99-2
CC-5013 hemihydrate
C03678-100mg
TNF-alpha
Apoptosis
Lenalidomide hemihydrate (CC-5013 hemihydrate) is a potent inhibitor of TNF-alpha with a IC50 of 13 nM. It induces tyrosine phosphorylation of CD28 on T cells, which subsequently activates NF-κB. It acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN), leading to the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase complex.
Beschrijving
Lenalidomidehemihydraat Beschikbaar in 100 mg. Bestel eenvoudig online met snelle levering.
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