Leoidin
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Leoidin is an OATP1B1 and OATP1B3 inhibitor with Ki values of 0.08 and 1.84 μM, respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC50= 42 μM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides[1][2].
105350-54-7
12352005
Bacterial
Anti-infection
COVID-19-immunoregulation
Infection
O=C(C1=C(O)C(C)=C(C(OC2=C(Cl)C(O)=C(Cl)C(C)=C23)=C1C)OC3=O)OC
C18H14Cl2O7
413.21
[1]De Bruyn T, et al. Structure-based identification of OATP1B1/3 inhibitors. Mol Pharmacol. 2013 Jun;83 (6) :1257-67. |[2]Hu Y, et al. Discovery and Analysis of Natural-Product Compounds Inhibiting Protein Synthesis in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2016 Jul 22;60 (8) :4820-9.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-N8497/
Natural Products
No Development Reported
Beschrijving
Leoidin is an OATP1B1 and OATP1B3 inhibitor with Ki values of 0.08 and 1.84 μM, respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing
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