LEP-antilichaam

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

3952

P41159

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 22-167 of human LEP (NP_000221.1) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Growth Factors, Neuroscience, Obesity, Signal Transduction, Stem Cell

Affinity purification

Mouse pancreas

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 17kDa

IgG

LEP

Leptin

Homo sapiens

OB Gene Product; Obese Factor

WB, IF

Liquid