Lever Artinase Antilichaam / ARG1

Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1) . Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.

Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL

P05089

Human

A portion of amino acids 1-200 from human ARG1 protein was used as the immunogen for the Liver Arginase antibody.

ARG1/9447

IHC-P, WB

Protein G affinity

Purified

This Liver Arginase antibody is available for research use only.

Aliquot the Liver Arginase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

1 mg/mL in 1X PBS; BSA free, sodium azide free

Optimal dilution of the Liver Arginase antibody should be determined by the researcher.

Cytoplasm

Western blot testing of human liver tissue lysate with Liver Arginase antibody (clone ARG1/9447) . Predicted molecular weight ~35 kDa.