Lewis y tetrasaccharide

Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide. Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis[1][2].

82993-43-9

Lewis y

12352005

FAK

Protein Tyrosine Kinase/RTK

Cancer-Kinase/protease

Cancer

99.64

H2O : 125 mg/mL (ultrasonic)

O[C@@H]([C@@H]([C@@H]([C@@H](O1)C)O)O)[C@@H]1O[C@H]([C@H](C=O)NC(C)=O)[C@@H]([C@H](O)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)O[C@H]3[C@H]([C@@H]([C@@H]([C@@H](O3)C)O)O)O

C26H45NO19

675.63

[1]Yan LM, et al. Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin alpha5beta1 with the Lewis Y-structure on transfection of the alpha1,2-fucosyltransferase gene. Biochimie. 2010 Jul;92 (7) :852-7. |[2]Yan L, et al. Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression. Biochimie. 2015 Jun;113:17-25.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-N10535/Lewis-y-tetrasaccharide-SDS-MedChemExpress.pdf

Natural Products

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