LFNG Antibody - N-terminal regio : HRP (ARP44923_P050-HRP)

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

SCDO3

3955

Q8NES3-3

NP_001035258

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Yeast

The immunogen is a synthetic peptide directed towards the N terminal region of human LFNG

This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150) . Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3.

APP; NOTCH2; NOTCH1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Yeast: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

39kDa

Sparrow, D.B., (2006) Am. J. Hum. Genet. 78 (1), 28-37

Wet Ice

361

LFNG

LFNG

Rabbit

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

NM_001040168

LSEYFSLLTRARRDAGPPPGAAPRPADGHPRPLAEPLAPRDVFIAVKTTK