LGP2 Antilichaam

LGP2 Antibody: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling.

79132

Q96C10

EAW60798

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

LGP2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1465 - Rat Kidney Tissue Lysate

1 mg/mL

LGP2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LGP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of LGP2 are known to exist.

DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58

Homo sapiens

Akira S, Uematsu S, and Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801.

Iwasaki A and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 2004; 5:987-95.

Yoneyama M, Kikuchi K, Matsumoto K, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004; 5:730-7.

Andrejeva J, Childs KS, Young DF, et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibits its activation of the IFN-betta promoter. Proc. Natl. Acad. Sci. USA, 2004; 101:17264-9.

LGP2 Antibody: LGP2, RLR-3, D11LGP2, D11lgp2e, D11LGP2E, LGP2, Probable ATP-dependent RNA helicase DHX58, Probable ATP-dependent helicase LGP2

ELISA, WB

119581202

Liquid