LIG4 Antilichaam - N-terminalgebied: FITC (ARP34122 T100-FITC)

Ligase IV, DNA, ATP-dependent

LIG4S

3981

Q8IY66

NP_002303

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human LIG4

LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V (D) J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ) . This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK) . Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.

XRCC4; UBC; AGO2; GZMK; ZSCAN18; PHF10; PNKP; TSFM; PRKDC; GUSBP3; NOMO3; FBLL1; PGP; ASPM; AMZ2P1; PPP1R18; COMMD1; ZNF428; AGAP4; WDR20; RPS19BP1; ZFAND2A; FIP1L1; CCDC176; VKORC1; COA7; SOWAHC; SEMA4G; ALMS1; WARS; UBE2L3; UBB; TPT1; TPI1; TP53BP1; TLE

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 92%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

104kDa

Smith, J., et al., (2003) Nucleic Acids Res. 31 (8), 2157-2167

Wet Ice

911

LIG4

LIG4

Rabbit

DNA ligase 4

NM_002312

DGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQ