LIMK1 (fosfo Thr508) Antilichaam

Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.

3984

P53667

NP_002305.1

Human, Mouse, Rat

LIMK1 (Phospho-Thr508) antibody was raised against a peptide sequence around phosphorylation site of threonine 508 (R-Y-T (p) -V-V) derived from Human LIMK1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

72 kDa

This antibody detects endogenous level of LIMK1 only when phosphorylated at threonine 508.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

LIMK1

LIM domain kinase 1

Homo sapiens

Soosairajah J, et al. (2005) EMBO J. Ohashi K, et al. (2000) J Biol Chem; 275 (5) : 3577-82. Edwards DC, et al. (1999) Nat Cell Biol; 1 (5) : 253-9.

LIMK, LIMK-1, C1orf215, LAP18, OP18, kinase LIMK1

WB, IHC, IF

4505001

Liquid