Lin28 Antilichaam

Lin28 Antibody: Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

79727

Q9H9Z2

EAX07814

Human

Unconjugated

Primary Antibodies

Stem Cell

Lin28 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (87%), Chicken: (79%)

Lin28 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Lin28 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

LIN28A

Cat. No. 10-901 - Human Spleen Tissue Slide

Lin-28 homolog (C. elegans)

Homo sapiens

Ambros V. A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. Cell1989; 57:49-57.

Carpenter MK, Rosler E, and Rao MS. Characterization and differentiation of human embryonic stem cells. Cloning Stem Cells2003; 5:79-88.

Tyu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science2007; 318:1917-20

Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science2008; 322:949-53.

Lin28 Antibody: CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A, CSDD1, Protein lin-28 homolog A, Zinc finger CCHC domain-containing protein 1, Lin-28A

ELISA, WB, IHC-P, IF

119628219

Liquid