Lin28 Antilichaam

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.

79727

Q9H9Z2

NP_078950.1

Human, Mouse, Rat

Lin28 antibody was raised against a peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Human Lin28 .

Unconjugated

Primary Antibodies

Stem Cell

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

26 kDa

This antibody detects endogenous levels of total Lin28 protein.

Western Blot: 1:1000

LIN28A

Lin-28 homolog A (C. elegans)

Homo sapiens

Heo I., Joo C., Mol. et al., Cell 32:276-284 (2008) Heo I., Joo C., Kim Y. -K., et al., Cell 138:696-708 (2009) Viswanathan S. R., Powers J. T., et al., Nat. Genet. 41:843-848 (2009)

CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A, CSDD1, LIN28A

WB

13375938

Liquid