Lin28 Antilichaam1G9]

Lin28 Monoclonal Antibody: Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

79727

Q9H9Z2

NP_078950

Human

1G9H9

Unconjugated

Primary Antibodies

Stem Cell

Lin28 Monoclonal Antibody is affinity chromatography purified via peptide column.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (87%), Chicken: (79%)

Lin28 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Lin28 Monoclonal antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 23 kDa

IgG2b

At least two isoforms of Lin28 are known to exist; this antibody will detect both. Lin28 antibody will not cross-react with Lin28 Homolog B.

LIN28A

Lin-28 homolog A (C. elegans)

Homo sapiens

Ambros V. A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. Cell 1989; 57:49-57.

Carpenter MK, Rosler E, and Rao MS. Characterization and differentiation of human embryonic stem cells. Cloning Stem Cells 2003; 5:79-88.

Tyu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318:1917-20

Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322:949-53.

Lin28 Antibody [1G9H9] : CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A

ELISA, WB

13375938

Liquid