LIN54 Antilichaam

LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes. This complex functions as a transcriptional repressor by binding to promoters of E2F target genes that regulate the G1/S transition (1) . LIN54 is required for cell cycle progression and can bind to the cdc2 promoter in a sequence-specific manner (2) .

132660

Q6MZP7

NP_919258

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cell Cycle

LIN54 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

LIN54 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LIN54 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

LIN54 antibody is human, mouse, and rat reactive. Multiple isoforms of LIN54 are known to exist.

LIN54

Cat. No. 17-001 - HeLa Cell Slide

Lin-54 homolog (C. elegans)

Homo sapiens

Schmit F, Cremer S, and Gaubatz S. LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promotoer in a sequence-specific manner. FEBS J. 2009; 276:5703-16.

Matsuo T, Kuramoto H, Kumazaki T, et al. LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression. Cell Cycle 2012; 11:3227-36.

LIN-54, JC8.6, CXCDC1, MIP120

ELISA, WB, ICC, IF

169234719

Liquid