LIN7C Antilichaam - middengebied: Biotine (ARP42908 P050-Biotine)

Lin-7 homolog C (C. elegans)

MALS3, VELI3, LIN-7C, MALS-3, LIN-7-C

55327

Q9NUP9

NP_060832

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human LIN7C

LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

UBC; AMOTL2; LATS2; YAP1; Wwtr1; CFTR; ELAVL1; AMOT; UIMC1; SPATA2; KCNJ12; BAIAP2; ABCA1; HTR2C; CASK; KCNJ4; DLG1; APBA1

Biotin

Polyclonal Antibody

WB, IHC

Affinity Purified

LIN7C is supported by BioGPS gene expression data to be expressed in MCF7

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

22kDa

Lanktree, M., (er) Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008) In press

Wet Ice

197

LIN7C

LIN7C

Rabbit

Protein lin-7 homolog C

NM_018362

MGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV