Lipopolysacchariden uit Akkermansia muciniphila

Lipopolysaccharides, from Akkermansia muciniphila (LPS, from Akkermansia muciniphila) are lipopolysaccharide endotoxins derived from Akkermansia muciniphila and are TLR-4 activators. Unlike typical LPS, Lipopolysaccharides, from Akkermansia muciniphila are R-type LPS or lipooligosaccharides (LOS), lacking the O-antigen domain and consisting only of a core oligosaccharide and a lipid A. Lipopolysaccharides, from Akkermansia muciniphila can activate TLR4 and TLR2, and may inhibit the TLR4/NF-κB pathway, thereby alleviating LPS-induced acute kidney injury[1][2]. It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

LPS, from Akkermansia muciniphila

12352200

Biochemical Assay Reagents

Others

Inflammation/Immunology

[Lipopolysaccharides,fromAkkermansiamuciniphila]

[1]Garcia-Vello P, et al. The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity. Nat Commun. 2024 Sep 27;15 (1) :8411.|[2]Shi J, et al. Akkermansia muciniphila attenuates LPS-induced acute kidney injury by inhibiting TLR4/NF-κB pathway. FEMS Microbiol Lett. 2022 Nov 17;369 (1) :fnac103.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-D1056I/

Biochemical Assay Reagents

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