α-Lipozuur (natrium) (standaard)

α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

2319-84-8

Thioctic acid (sodium) (Standard) ; (±) -α-Lipoic acid (sodium) (Standard) ; DL-α-Lipoic acid (sodium) (Standard)

12352005

Apoptosis; Endogenous Metabolite; HIV; Mitochondrial Metabolism; NF-κB; Reference Standards

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; NF-κB; Others

Cancer; Infection; Inflammation/Immunology

O=C(O[Na])CCCCC1SSCC1

C8H13NaO2S2

228.31

[1]Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27 (1-4) :157-65.|[2]Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9 (15) :12137-12153.|[3]Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25 (11) :1207-1217.|[4]Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10 (1) :7139.|[5]Liu J, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir, 2022.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N0492AR/

Reference Standards