LKB1 Antilichaam

LKB1 Antibody: The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK) . Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium.

6794

Q15831

AAH19334

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction, Cancer

LKB1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1216 - PC-3 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%), Chicken: (87%)

LKB1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LKB1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

STK11

Serine/threonine kinase 11

Homo sapiens

Hemminki A, Markie D, Tomlinson I, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391:184-7.

Boudeau J, Baas AF, Deak M, et al. MO25α /β interact with STRADα /β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J. 2003; 22:5102-14.

Hawley SA, Boudeau J, Reid JL, et al. Complexes between the LKB1 tumor suppressor, STRADα /β and MO25α /β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2003; 2:28

LKB1 Antibody: PJS, LKB1, hLKB1, PJS, Liver kinase B1

ELISA, WB

17939640

Liquid