LMNB1 Antilichaam - middelste regio : HRP (ARP46137 P050-HRP)

Lamin B1

LMN, ADLD, LMN2, LMNB, MCPH26

4001

P20700

NP_005564

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human LMNB1

LAMNB1 encodes for one of the two B type proteins of the nuclear lamina, B1. The Vertebrate lamins consist of two types, A and B. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

POU2F1; SPRTN; UBC; SUMO2; SUMO3; MDM2; EED; ACTR10; NCAPH; ZZEF1; DCTN3; DCTN2; ACTR1A; ACTR1B; PARK2; HECW2; YWHAQ; ADRB2; LMNA; MELK; URB2; FN1; ATF4; SERPINA3; ABCG8; MBIP; GIT2; WHSC1; VCAM1; ITGA4; PRKCB; CDK1; MAGT1; HP1BP3; NCSTN; HNRNPM; EIF6; IL

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

LMNB1 is supported by BioGPS gene expression data to be expressed in SKMEL2

0.5 mg/ml

Cow: 86%; Dog: 100%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 91%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

66kDa

Lee, T.H., PLoS Med. 4 (6), E186 (2007)

Wet Ice

586

LMNB1

LMNB1

Rabbit

Lamin-B1

NM_005573

EEVAQRSTVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM