LMX1A Antilichaam

LMX1A Antibody: The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.

4009

Q8TE12

NP_796372

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

LMX1A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (92%)

LMX1A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LMX1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms are known to exist. This antibody is predicted to not cross-react with LMX1B.

Human LMX1A has two isoforms, including isoform 1 (382aa, 42.7kD) and isoform 2 (133aa, 14.6kD) . Mouse LMX1A one isoform (382aa, 42.9kD), and ratt LMX1A has one isoform (382aa, 42.8kD) . 7087 can detect human, mouse and rat.

LMX1A

Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate

LIM homeobox transcription factor 1, alpha

Homo sapiens

Failli et al. Mech. Dev. 2002; 118:225-8.

Nakatani et al. Biol. 2010; 339:101-13.

Chizhikov and Millen. Development 2004; 131:2693-705.

Lin et al. Am. J. Clin. Pathol. 2012; 137:971-7.

LMX1A Antibody: LMX1, LMX1.1, LIM homeobox transcription factor 1-alpha

ELISA, ICC/IF, IHC-P, WB

28893581

Liquid