LPAM 1 (Integrin a4, CD49d) Antilichaam

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

3676

P13612

NP_000876.3

Human

LPAM-1 (Integrin a4, CD49d) antibody was raised against a peptide sequence around aa.1024~1028 (Y-I-N-S-K) derived from Human LPAM-1 (Integrin α4, CD49d) .

Unconjugated

Primary Antibodies

Stem Cell

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

70, 140, 180 kDa

This antibody detects endogenous level of total LPAM-1 (Integrin α4, CD49d) protein.

Western Blot: 1:500~1:1000

ITGA4

Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Homo sapiens

Iida J., Meijne A. M. L., Oegema T. R. Jr., Yednock T. A., Kovach N. L., Furcht L. T., McCarthy J. B. J. Biol. Chem. 273:5955-5962 (1998) Liu S., Thomas S. M., Woodside D. G., Rose D. M., Kiosses W. B., Pfaff M., Ginsberg M. H. Nature 402:676-681 (1999)

IA4, CD49D, CTNNB, OK/SW-cl.35, PRO2286, IA4, MGC90518, ITGA4

WB

67191027

Liquid