Lpathomab
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control[2].
1253114-37-2
LT3015; LT-3000
12352203
LPL Receptor
GPCR/G Protein
Cancer-programmed cell death
Cancer; Neurological Disease
[Lpathomab]
[1]Visentin B, et al. Abstract# 1247: In vitro and in vivo efficacy of Lpathomab\# 8482; , a monoclonal antibody directed against lysophosphatidic acid (LPA), in ovarian cancer models[J]. Cancer Research, 2009, 69 (9_Supplement) : 1247-1247.|[2]Crack PJ, et al. Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes. J Neuroinflammation. 2014 Feb 27;11:37.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991310/
Inhibitory Antibodies
No Development Reported
Beschrijving
Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and
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