LPIN1 Antilichaam

LPIN1 Antibody: LPIN1, also known as PAP1, is a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol (reviewed in 1) . LPIN1 is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism (1,2) . Mutations in LPIN1 are associated with metabolic diseases such as type 2 diabetes and recurrent acute myoglobinuria (3,4) and it is also a candidate for several human lipodystrophy syndromes (5) .

23175

Q14693

NP_001248357

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

LPIN1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

LPIN Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LPIN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Other LPIN1 antibodies show similar size band

IgG

LPIN1 antibody is human and mouse reactive. At least four isoforms of LPIN1 are known to exist.

LPIN1

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Lipin 1

Homo sapiens

Reue K and Zhang P. The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS Lett. 2008; 582:90-6.

Peterfy M, Phan J, Xu P, et al. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 2001; 27:121-4.

Zhang R, Jiang F, Hu C, et al. Genetic variants of LPIN1 indicate an association with Type 2 diabetes mellitus in a Chinese population. Diabet. Med. 2013; 30:118-22.

Zeharia A, Shaag A, Houtkooper RH, et al. Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood. Am. J. Hum. Genet. 2008; 83:489-94.

LPIN1 Antibody: PAP1, KIAA0188, Phosphatidate phosphatase LPIN1, Lipin-1

ELISA, WB, IHC-P, IF

387528013

Liquid