LRFN1 Antilichaam

LRFN1 Antibody: LRFN1 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR) -immunoglobulin-like (Ig) -fibronectin type III (Fn) -transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN1 are known to exist.

57622

Q9P244

Q9P244

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

LRFN1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

LRFN1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LRFN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody is predicted to not cross-react with other members of the LRFN family.

LRFN1

Leucine rich repeat and fibronectin type III domain containing 1

Homo sapiens

Morimura N, Inoue T, Katayama K, et al. Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. Gene2006; 380:72-83.

Kobe B and Kajava AV. The leucine-rich repeat as a protein recognition motif. Curr. Opin. Struct. Biol.2001; 11:725-32.

Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci.2003; 24:117-29.

LRFN1 Antibody: SALM2, KIAA1484, SALM2, Leucine-rich repeat and fibronectin type III domain-containing protein 1, Synaptic adhesion-like molecule 2

ELISA, WB, IHC-P, IF

189028858

Liquid