LRP1 Antilichaam

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712) . This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.

4035

Q07954

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human LRP1 (NP_002323.2) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle, Immunology, Neuroscience, Signal Transduction

Affinity purification

SH-SY5Y

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 95kDa

IgG

WB: 1:500 - 1:1000

LRP1

Low density lipoprotein receptor-related protein 1

Homo sapiens

LRP1, APR, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R

WB

Liquid