LRRC8A Antilichaam

The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1,2) . LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1) . LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3) .

56262

Q8IWT6

NP_062540

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Signal Transduction

LRRC8A antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

LRRC8A antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LRRC8A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Multiple other LRRC8A antibodies also show a ~95kD band

IgG

LRRC8A antibody is human, mouse and rat reactive.

LRRC8A

Leucine rich repeat containing 8 family, member A

Homo sapiens

Sawada A, Takihara Y, Kim JY, et al. A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. J. Clin. Invest. 2003; 112:1707-13.

Kubota K, Kim JY, Sawada A, et al. LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins. FEBS Lett. 2004; 564:147-52.

Voss FK, Ullrich F, Munch J, et al. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science 2014; 344:634-8.

Leucine rich repeat containing 8 family member A, leucine-rich repeat-containing protein 8A, LRRC8, AGM5

ELISA, WB, IHC-P

62241040

Liquid