LRRFIP1 Antilichaam

LRRFIP1 Antibody: LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a beta-catenin-dependent pathway.

9208

Q32MZ4

NP_001131024

Human

Unconjugated

Primary Antibodies

Signal Transduction

LRRFIP1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1320 - Human Colon Tissue Lysate

1 mg/mL

LRRFIP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LRRFIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

LRRFIP1 antibody is predicted to not cross-react with other LRRFIP family members. Three isoforms of LRRFIP1 are known to exist; this antibody will only recognize the two longer isoforms.

LRRFIP1

Leucine rich repeat (in FLII) interacting protein 1

Homo sapiens

Rikiyama T, Curtis J, Oikawa M, et al. GCF2: expression and molecular analysis of repression. Biochim. Biophys. Acta 2003; 1629:15-25.

Suriano AR, Sanford AN, Kim N, et al. GCF2/LRRFIP1 represses tumor necrosis factor α expression. Mol. Cell. Biol. 2005; 25:9073-81.

Wilson SA, Brown EC, Kingsman AJ, et al. TRIP: a novel double-stranded RNA binding protein which interacts with the leucine-rich repeat of Flightless I. Nucleic Acids Res. 1998; 26:3460-7.

Goodall AH, Burns P, Salles I, et al. Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood 2010; 116:4646-56.

LRRFIP1 Antibody: GCF2, TRIP, FLAP1, GCF-2, FLAP-1, HUFI-1, FLIIAP1, GCF2, Leucine-rich repeat flightless-interacting protein 1, GC-binding factor 2, LRR FLII-interacting protein 1

ELISA, WB, IHC-P, IF

212276096

Liquid