LTD4-antagonist 3

LTD4 antagonist 3 (FK011 hydrochloride) is a LTD4 antagonist. LTD4 antagonist 3 has agonistic activity for PPAR-γ, with a fold-increase of 1.50 at 1 μM and 2.35 at 10 μM. LTD4 antagonist 3 can be used of development of non-steroidal anti-inflammatory drugs (NSAIDs) [1].

149437-51-4

FK011 (hydrochloride)

12352005

Leukotriene Receptor; PPAR

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

COVID-19-anti-virus

Inflammation/Immunology

O=C(CC1=C(COC2=CC3=C(OC(C4=NC(C(C)(C)C)=CS4)=C3)C=C2)C=CC=C1)O.Cl

C24H24ClNO4S

457.97

[1]Kojo H, et al. Evaluation of human peroxisome proliferator-activated receptor (PPAR) subtype selectivity of a variety of anti-inflammatory drugs based on a novel assay for PPAR delta (beta) . J Pharmacol Sci. 2003 Nov;93 (3) :347-55.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19178/

Reference compound1

Phase 2

LTD4/CysLT1; PPARγ