Lu AF58786

Lu AF58786 is a potent and selective LRRK2 inhibitor with an IC50 of 12 nM. Lu AF58786 also exhibits inhibition activity against LRRK2 G2019S and LRRK2 A2016T with IC50s of 19 and 93 nM. Lu AF58786 inhibits phosphorylation of LRRK2, Rab10 and Rab12 in human peripheral blood mononuclear cells. Lu AF58786 can be used for parkinson’s disease research[1][2].

1632368-13-8

12352005

LRRK2

Autophagy

Neurological Disease

N#CC1=CNC2=NC(NC3=NN(C)C=C3)=CC(C4=CC(C)=CC=C4)=C12

C19H16N6

328.37

[1]Thirstrup K, et al. Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells. Sci Rep. 2017 Aug 31;7 (1) :10300.|[2]Williamson DS, et al. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1) . J Med Chem. 2017 Nov 9;60 (21) :8945-8962.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180320/

Reference compound1

No Development Reported