Gecertificeerd

Luspatercept (mIgG2a)

Name: Luspatercept (mIgG2a)
Brand: Genprice.nl
SKU: 26527153
Availability: InStock

Catalog #: HY-P99720A

Maat: 1 Each

Kwaliteit

ISO Gecertificeerd

Levering

24-48 uur

Prijs -1%

BTW niet inbegrepen

Gratis verzending vanaf €100

Aantal:

Technische Specificaties

Description

Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects[1].

CAS Number

1373715-00-4

Product Name Alternative

RAP-536

UNSPSC

12352203

Target

TGF-beta/Smad

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Metabolic Disease

Smiles

[Luspatercept(mIgG2a)]

References & Citations

[1]Suragani RN, et al. Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia. Blood. 2014 Jun 19; 123 (25) :3864-72.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P99720A/

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Beschrijving

Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspat

Specificaties

ProductnaamLuspatercept (mIgG2a)

Categorie

Beschikbare grootte1 Each

CatalogusnummerHY-P99720A

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