Ly-49C/F/H/I Antilichaam [14B11]

The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J) .

16634;16637;16639;16640

Q64329

Q64329

Mouse

IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice

[14B11]

Unconjugated

Primary Antibodies

Immunology

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG

Ly-49C/F/H/I

Ly-49C/F/H/I Antibody [14B11] for use in flow cytometry and cytotoxicity assays.

Klra3

Killer cell lectin-like receptor, subfamily A, member 3

Mus musculus

Ly-49

WB, IHC-P, IHC-Fr, ICC, Flow

Liquid