Ly-6A/E Antilichaam [D7] (APC)

Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.

110454

P05533

P05533

Mouse

IL-2 dependent mouse (C57BL/6) cytotoxic T cell line CTL-L

[D7]

APC

Primary Antibodies

Innate Immunity, Stem Cell

0.1 mg/mL

Supplied in PBS/NaN3 and a stabilizing agent

None

Blue Ice

Store vial at 2-8˚ C

IgG2a

Ly-6A/E

Ly-6A/E Antibody [D7] for use in flow cytometry assays.

Ly6a

Lymphocyte antigen 6 complex, locus A

Mus musculus

Sca-1

Flow

Liquid