LY6G6D, menselijk (HEK293, Fc)

LY6G6D Protein is a leukocyte antigen-6 (LY6) gene cluster located in the Major Histocompatibility complex (MHC) Class III region of chromosome 6. LY6G6D Protein is involved in the JAK-STAT5 and RAS-MEK-ERK signaling pathways, and is a selective expression of colorectal cancer antigen. Therapeutic T-cell responses can be targeted through T-cell adaptors. LY6G6D Protein, Human ((HEK293, Fc) is the recombinant human-derived LY6G6D protein, expressed by heterologous system, with N-hFc labeled tag.

LY6G6D Protein, Human (HEK293, Fc), Human, HEK293

12352202

58530 (Gene_ID) O95868 (N20-S104) (Accession)

Approximately 38-43 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

[1]Corrales L, et al. LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager. Front Immunol. 2022 Sep 8;13:1008764.|[2]Giordano G, et al. JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer. J Exp Clin Cancer Res. 2019 Jan 22;38 (1) :28.|[3]Loughner CL, et al. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Hum Genomics. 2016 Apr 21;10:10.|[4]Mallya M, et al. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. Genomics. 2002 Jul;80 (1) :113-23.

Room temperature in continental US; may vary elsewhere.

Recombinant Proteins