LY6K Antilichaam

LY6K Antibody: The lymphocyte antigen 6 complex locus K (LY6K), a member of cancer-testis antigen was initially identified as a molecular marker for head-and-neck squamous cell carcinoma as well a breast cancer. LY6K is a GPI-anchored membrane protein that is specifically associated with germ cell marker TEX101 and is strongly observed in testis, but only weakly in other tissues. LY6K mRNA was found to be upregulated in numerous bladder cancers due to gene amplification. Furthermore, knockdown experiments using LY6K siRNA reduced cell growth, migration and invasion in bladder carcinoma cell lines, suggesting that LY6K contributes to bladder cancer development.

54742

Q17RY6

EAW82311

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

LY6K Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

LY6K Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

LY6K antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Multiple isoforms of LY6K are known to exist.

LY6K

Lymphocyte antigen 6 complex, locus K

Homo sapiens

De Nooij-van Dalen AG, van Dongen GA, Smeets SJ, et al. Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma. Int. J. Cancer 2003; 103:768-74.

Lee JW, Lee YS, Yoo KH, et al. LY-6K gene: a novel molecular marker for human breast cancer. Oncol. Rep. 2006; 16:1211-4.

Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, et al. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus K within the mouse testis. Biochem. Biophys. Res. Commun. 2008; 372:277-82.

Maruyama M, Yoshitake H, Tsukamoto H, et al. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells. Biochem. Biophys. Res. Commun. 2010; 402:75-81.

LY6K Antibody: CT97, ly-6K, HSJ001348, CO16, Lymphocyte antigen 6K, Ly-6K

ELISA, WB

237820711

Liquid