LYN Antibody - N-terminal regio : HRP (ARP54696_P050-HRP)

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

JTK8, p53Lyn, p56Lyn

4067

P07948

NP_002341

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the N terminal region of human LYN

LYN down regulates expression of stem cell growth factor receptor (KIT) .LYN acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.LYN acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents.LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.

UBC; IKBKG; TRIM28; EGFR; RGS16; TNF; IL1B; ANGPT2; DKFZP434K028; CNOT10; TGDS; CBX6; FBXO28; ZNF423; RASSF8; FRS2; HBS1L; TUBB4A; SH2D3C; RIMS2; DDX21; KYNU; TNFSF12; PIK3R3; YEATS4; ZNF189; UGP2; HSP90B1; TADA2A; SLC12A4; RDX; PRKCB; SCIMP; LNP1; RNF180

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

LYN is strongly supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%; Sheep: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

58kDa

Wet Ice

512

LYN

LYN

Rabbit

Tyrosine-protein kinase Lyn

NM_002350

DPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSF