LYN-antilichaam [2H8D7]

Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI) .

4067

P07948

P07948

Human

Ni-NTA purified truncated recombinant Lyn expressed in E. Coli strain BL21 (DE3) .

2H8D7

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

LYN monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2b

LYN

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Homo sapiens

Sakaguchi, A.Y., et al.Genet. 34: 175.

Hibbs, M.L., et al.Biol. 29: 397-400.

Williams, J.C., et al.Trends Biochem. Sci. 23: 179-184.

JTK8, V-yes-1 Yamaguchi sarcoma viral related oncogene homologJTK8, p53Lyn, p56Lyn

ELISA

125480