[Lys5, Tyr6, mlleu9, Nle10]-Neurokinine A (4-10)

[Lys5, Tyr6, mLeu9, Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. [Lys5, Tyr6, mLeu9, Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide -induced dysfunctional voiding in wild-type mice. [Lys5, Tyr6, mLeu9, Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research[1].

2770688-04-3

12352209

Neurokinin Receptor

GPCR/G Protein; Neuronal Signaling

Metabolic Disease

N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@H](C(NCC(N([C@@H](CC(C)C)C(N[C@@H](CCCC)C(N)=O)=O)C)=O)=O)C(C)C)=O)=O)CCCCN)=O

C39H65N9O10

819.99

[1]Gustafsson M B F, et al. Compounds and their use in treatment of tachykinin receptor mediated disorders. WO2022096736A1. 2022-05-12.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11075/

Peptides

No Development Reported

NK2R; NK3R