M6903
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM) . M6903 binds to TIM-3, blocking the binding of TIM-3 to phosphatidylserine (PtdSer), carcinoembryonic antigen cell adhesion-related molecule 1 (CEACAM1), and galectin 9 (Gal-9), thus relieving TIM-3-mediated T cell inhibition and exerting the activities of activating antigen-specific T cells and enhancing anti-tumor immunity. M6903 is promising for research of cancers[1].
12352203
Tim3
Immunology/Inflammation
Cancer-programmed cell death
Cancer
98.81
(142 kDa)
[1]Zhang D, et al. Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Oncoimmunology. 2020 Apr 1;9 (1) :1744921.
Dry Ice
-80°C
http://file.medchemexpress.com/batch_PDF/HY-P991198/M6903-SDS-MedChemExpress.pdf
Inhibitory Antibodies
No Development Reported
Beschrijving
M6903 is a humanized monoclonal IgG2 antibody targeting T cell immunoglobulin and mucin domain-3 (TIM-3) (KD for human TIM-3 is 2.3 nM) . M6903 binds to TIM-3,
Specificaties
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