MAART2 Antilichaam - middengebied HRP (ARP42966_P050-HRP)

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase

MARCH2, RNF172, HSPC240, MARCH-II

51257

Q9P0N8

NP_001005415

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human MARCH2

MARCH2 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH2 may be involved in endosomal trafficking through interaction with STX6.

LDLRAD1; SYNE4; CCDC155; FATE1; UBE2H; UBE2D1; CDC34; GOPC; STX6; CFTR; ADRB2; ELAVL1; DLG1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

27kDa

Cao, Z., (2008) Cell. Signal. 20 (1), 73-82

Wet Ice

246

44987

MARCH2

Rabbit

E3 ubiquitin-protein ligase MARCH2

NM_001005415

LFITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIALTIALFTIYVLWTLV