MACC1 Antilichaam

MACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF) -HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD) . Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.

346389

Q6ZN28

NP_877439

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer

MACC1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1404 - Mouse Liver Tissue Lysate

1 mg/mL

MACC1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MACC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of MACC1 are known to exist.

MACC1

Cat. No. 10-201 - Human Liver Tissue Slide

Cat. No. 1304 – Human Liver Tissue Lysate

Metastasis associated in colon cancer 1

Homo sapiens

Stein U, Walther W, Arlt F, et al. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat. Med.2009; 15:59-67.

Boardman LA. Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer. Genome Med.2009; 1:36.

Stein U, Smith J, Walther W, et al. MACC1 controls Met: what a difference an Sp1 site makes. Cell Cycle2009; 8:2467-9.

Arlt F and Stein U. Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. Int. J. Biochem. Cell Biol.2009; epub.

MACC1 Antibody: 7A5, SH3BP4L, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5

ELISA, WB, IHC-P, IF

157502191

Liquid