MACTIDE-V

MACTIDE-V is an orally active and selective peptide-drug conjugate targeting CD206. MACTIDE-V delivers Verteporfin to CD206+ tumor-associated macrophages (TAM) to inhibit the YAP/TAZ signaling pathway, prompting YAP exclusion from the nucleus, inducing TAM polarization toward an anti-tumoral phenotype with enhanced phagocytosis and antigen presentation, and boosting T cell infiltration and NK cell activity. MACTIDE-V suppresses primary tumor growth and lung metastasis in triple-negative breast cancer (TNBC) mouse models[1].

12352209

Epigenetic Reader Domain; YAP

Epigenetics; Stem Cell/Wnt

Cancer-programmed cell death

Cancer

C[C@]1(/C2=C/C(N3)=C4C)C(C(/C=C(C(C)=C/5C=C)\NC5=C/C6=N/C(C(CCC(OC)=O)=C6C)=C\C3=C4CCC(NCCCCCC(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N7[C@@H](CCC7)C(NCC(N[C@@H](C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)NC8=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N9[C@@H](CCC9)C(N%10[C@@H](CCC%10)C(N[C@H]8[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=N2)=CC=C(C(OC)=O)[C@H]1C(OC)=O

C109H156N22O27S2

2270.67

[1]Lepland A, et al. Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer. Adv Sci (Weinh) . 2025 Mar;12 (10) :e2410288.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10947/

Peptides

No Development Reported