Mafa Antibody - C-terminal regio : Biotine (ARP37614 P050-Biotin)

V-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)

RIPE, RIPE3b1

378435

Q8CF90

NP_919331

Human, Mouse, Rat

The immunogen is a synthetic peptide corresponding to a region of Mouse

Mafa acts as a transcriptional factor. Mafa specifically binds the insulin enhancer element RIPE3b. Mafa cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Mafa regulates the insulin gene transcription. Mafa is involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Psme3

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 86%; Mouse: 100%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

37kDa

Wet Ice

359

MAFA

Mafa

Rabbit

Transcription factor MafA

NM_194350

KLEVGRLAKERDLYKEKYEKLAGRGGPGGAGGAGFPREPSPAQAGPGAAK