MAGEA4 Antilichaam

MAGEA4 is a member of the melanoma-associated antigen family that consists of a number of antigens recognized by cytotoxic T lymphocytes (1) . MAGEA4 may serve as a target for antitumoral vaccination and may play a role in embryonal development and tumor transformation or aspects of tumor progression. It is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma and have been implicated in some hereditary disorders, such as dyskeratosis congenital (2-4) .

4103

P43358

NP_001011550

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Cancer

MAGEA4 antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/mL

MAGEA4 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MAGEA4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Multiple independent MAGEA4 antibodies also show a band at ~45 kDa

IgG

MAGEA4 antibody is human specific. At least four isoforms of MAGEA4 are known to exist.

MAGEA4

Cat. No. 10-001 - Human Breast Tissue Slide

Melanoma antigen family A, 4

Homo sapiens

Bhan S, Negi SS, Shao C, et al. BORIS binding to the promoters of cancer testis antigens, MAGEA2, MAGEA3, and MAGEA4, is associated with their transcriptional activation in lung cancer. Clin. Cancer Res. 2011; 17:4267-76.

Bhan S, Chuang A, Negi SS, et al. MAGEA4 induces growth in normal oral keratinocytes by inhibiting growth arrest and apoptosis. Oncol. Rep. 2012; 28:1498-502.

Saito T, Wada H, Yamasaki M, et al. High expression of MAGE-A4 and MHC class I antigens in tumor cells and induction of MAGE-A4 immune responses are prognostic markers of CHP-MAGE-A4 cancer vaccine. Vaccine, epub. 2014; S0264-410X (14) 01217-1.

Zhang QM, He SJ, Shen N, et al. Overexpression of MAGE-D4 in colorectal cancer is a potentially prognostic biomarker and immunotherapy target. Int. J. Clin. Exp. Pathol. 2014; 7:3918-27.

Melanoma antigen family A4, MAGE4, MAGE-41, MAGE4A, MAGE-4 antigen, MAGE4B, MAGE-X2, MAGE-X2 antigen, Melanoma-associated antigen 4

ELISA, WB, IHC-P, IF

58530871

Liquid